Toxicity of dibutyl phthalate and its metabolites in rats.
نویسندگان
چکیده
منابع مشابه
Mitochondrial effect of orally administered dibutyl phthalate in rats.
activity in liver homogenate from di-2-ethylhexyl phthalate (DEHP)-treated rats. Ohyama9) showed in vitro that PAEs inhibited mitochondrial respiration, with di-n-butyl phthalte (DBP) showing the strongest effect, and he concluded that PAEs were inhibitors of electron and energy transfer systems but not uncouplers. Takahashi10) also found inhibitory effects of PAEs on respiration in vitro and a...
متن کاملChronic toxicity and carcinogenic evaluation of diisononyl phthalate in rats.
Groups of 110 Fischer 344 rats/sex were fed diisononyl phthalate (DINP) at dietary levels of 0, 0.03, 0.3, and 0.6 wt% for periods up to 2 years. Interim sacrifices of 10 predesignated rats/sex/dose were at 6, 12, and 18 months with surviving animals sacrificed at 24 months. At study termination, survival was in excess of 60% for every group. At the mid or high dose, the following biological ef...
متن کاملChronic toxicity of di(2-ethylhexyl)phthalate in rats.
Fischer 344 rats were treated with 0, 100, 500, 2500, or 12,500 ppm di(2-ethylhexyl)phthalate (DEHP) in the diet for up to 104 weeks. Blood and urine were analyzed at weeks 26, 52, 78, and 104 from 10 animals per sex per group. Survival was slightly but not statistically reduced for rats receiving 12,500 ppm DEHP. Body weights and food consumption were significantly reduced for rats receiving t...
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Dibutyl phthalate (DBP) is a plasticizer used for many consumer products including cosmetics. Potential health concerns regarding DBP include reproductive and developmental toxicity, endocrine disruption and neurotoxicity. DBP is a high priority chemical as to reduction of exposure of children to it. Through reproductive toxicity studies, monobutyl phthalate (MBP) has been proposed to be the ac...
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ژورنال
عنوان ژورنال: Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene)
سال: 1986
ISSN: 0021-5082,1882-6482
DOI: 10.1265/jjh.41.775